This page explains what happens if Allopurinol and Lisinopril are taken together, according to official sources.
Severe hypersensitivity and Stevens-Johnson syndrome risk
Co-administration of ACE inhibitors with allopurinol significantly increases the incidence of severe allergic skin reactions and leukopenia.
Advise patients to immediately report any cutaneous rash, mucosal lesions, or fever. Discontinue both drugs at the first sign of allergy.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.