This page explains what happens if Amitriptyline and Azithromycin are taken together, according to official sources.
Synergistic QT prolongation and dangerous arrhythmia risk
Combining azithromycin with amitriptyline substantially elevates ventricular arrhythmia risk through dual additive delays in cardiac repolarization.
Avoid concurrent use. Select an alternative non-QT prolonging antibiotic (e.g. amoxicillin). If mandatory, baseline and serial ECG monitoring is required.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.