This page explains what happens if Amitriptyline and Diazepam are taken together, according to official sources.
Additive central nervous system depression and motor impairment
Concurrent use causes marked synergistic central nervous system depression, profound sedation, severe cognitive clouding, and high fall risk.
Use minimal therapeutic dosages and administer strictly at bedtime. Supervise ambulation in geriatric patients to prevent orthopedic fractures.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.