This page explains what happens if Amitriptyline and Omeprazole are taken together, according to official sources.
Elevated amitriptyline levels and anticholinergic toxicity
Omeprazole inhibits CYP2C19, increasing serum amitriptyline concentrations and accentuating anticholinergic side effects and cardiac toxicity.
Monitor for enhanced tricyclic side effects (sedation, dry mouth, blurred vision, constipation). Adjust amitriptyline dosage if necessary.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.