This page explains what happens if Amitriptyline and Sertraline are taken together, according to official sources.
CYP2D6 inhibition, marked tricyclic toxicity, and Serotonin Syndrome
Sertraline inhibits the CYP2D6 metabolism of amitriptyline, causing dangerous tricyclic accumulation, cardiac conduction defects, and Serotonin Syndrome.
Avoid combination unless under specialized psychiatric supervision with therapeutic drug monitoring and baseline ECG.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.