This page explains what happens if Amitriptyline and Tramadol are taken together, according to official sources.
Severe Serotonin Syndrome and convulsion hazard
Concurrent tramadol and amitriptyline significantly elevates seizure frequency and induces severe serotonergic hyperactivity.
Avoid concurrent administration. Substitute analgesia with paracetamol or non-serotonergic therapies.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.