This page explains what happens if Amitriptyline and Warfarin are taken together, according to official sources.
Fluctuating warfarin response and INR
Amitriptyline can alter warfarin hepatic clearance and protein binding, leading to unpredictable fluctuations in INR.
Check INR periodically until a stable therapeutic range is confirmed following amitriptyline initiation.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.