This page explains what happens if Aspirin and Ibuprofen are taken together, according to official sources.
Reduced effectiveness
Ibuprofen can reduce the cardioprotective benefits of aspirin. Take them spaced apart.
Take immediate-release low-dose aspirin at least 30 minutes before ibuprofen, or wait at least 8 hours after ibuprofen before taking aspirin.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.