This page explains what happens if Aspirin and Prednisone are taken together, according to official sources.
Stomach ulcer risk
Both irritate the stomach lining. Combined, the risk of ulcers and gastric bleeding is very high.
Co-prescribe a proton pump inhibitor (PPI) for mucosal gastroprotection if combination is essential. Always take doses with food.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.