This page explains what happens if Aspirin and Sertraline are taken together, according to official sources.
Increased risk of gastrointestinal bleeding
Concomitant aspirin and sertraline therapy significantly increases the risk of upper gastrointestinal hemorrhage.
Counsel patients on GI bleed symptoms. Consider adding a gastroprotective agent (e.g. omeprazole) in high-risk individuals.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.