This page explains what happens if Azithromycin and Sertraline are taken together, according to official sources.
Additive cardiac QT prolongation and ventricular arrhythmia risk
Both azithromycin and sertraline possess documented QT-prolonging capability; concurrent administration synergistically multiplies ventricular arrhythmia danger.
Avoid combination where possible. Prescribe non-macrolide antibiotics (e.g. amoxicillin/clavulanate). If unavoidable, perform baseline and follow-up ECG.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.