This page explains what happens if Azithromycin and Simvastatin are taken together, according to official sources.
Potential low risk of muscle toxicity
There are reports that azithromycin combined with simvastatin may increase muscle toxicity risk, although less than other macrolides. Contact your doctor if you experience muscle pain or weakness.
Observe for muscle symptoms during short-course azithromycin and notify your doctor if unusual soreness develops.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.