This page explains what happens if Ciprofloxacin and Prednisolone are taken together, according to official sources.
High risk of severe tendinitis and Achilles tendon rupture
Combining fluoroquinolones with corticosteroids multiplies the risk of severe tendinitis and Achilles tendon rupture up to fifty-fold, especially in elderly patients.
Avoid combination where alternatives exist. At the first sign of tendon pain or swelling, immediately cease athletic activity and contact your physician.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.