This page explains what happens if Clopidogrel and Omeprazole are taken together, according to official sources.
Reduced effectiveness
Omeprazole can reduce the effectiveness of clopidogrel. An alternative is preferable.
Avoid omeprazole/esomeprazole. Switch to acid-suppressing agents with negligible CYP2C19 inhibition such as pantoprazole or famotidine.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.