This page explains what happens if Diazepam and Tramadol are taken together, according to official sources.
Profound respiratory depression, coma, and fatal overdose risk
Concomitant opioid (tramadol) and benzodiazepine (diazepam) therapy carries an FDA boxed warning for profound respiratory depression, coma, and death.
Reserve concomitant prescribing for patients in whom alternative options are inadequate. Limit dosages and duration to the bare minimum; ensure naloxone access.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.