This page explains what happens if Diclofenac and Metformin are taken together, according to official sources.
Increased risk of metformin-associated lactic acidosis
Diclofenac can induce acute renal impairment, impairing metformin clearance and precipitating life-threatening lactic acidosis.
Ensure adequate hydration and monitor renal function. Limit NSAID duration to the minimum necessary.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.