This page explains what happens if Diclofenac and Prednisolone are taken together, according to official sources.
Extremely high peptic ulcer and gastrointestinal perforation risk
Concurrent diclofenac and prednisolone therapy multiplies gastric ulceration and perforation rates up to fifteen-fold compared to baseline.
Avoid concurrent administration. If clinically non-negotiable, always mandate high-dose PPI co-prescription and monitor for microcytic anemia.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.