This page explains what happens if Diclofenac and Sertraline are taken together, according to official sources.
Augmented risk of upper gastrointestinal bleeding
Sertraline impairs platelet hemostatic function, compounding the ulcerogenic potential of diclofenac and raising upper GI bleeding incidence.
Prescribe concurrent gastroprotection (e.g. omeprazole) in patients requiring both agents, or switch pain management to paracetamol.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.