This page explains what happens if Ibuprofen and Metformin are taken together, according to official sources.
Kidney strain
Ibuprofen can reduce kidney function and raise metformin levels, increasing the risk of lactic acidosis.
Maintain robust hydration and avoid excessive NSAID doses. Seek emergency care immediately if hyperventilation, myalgias, or somnolence develop.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.