This page explains what happens if Ibuprofen and Sertraline are taken together, according to official sources.
Elevated risk of upper GI bleeding
Co-administration of ibuprofen with sertraline significantly amplifies upper gastrointestinal hemorrhage risk.
Substitute with paracetamol for pain relief. If NSAID therapy is unavoidable, co-prescribe a protective PPI.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.