This page explains what happens if Levothyroxine and Prednisolone are taken together, according to official sources.
Suppression of TSH and impaired T4-to-T3 peripheral conversion
Prednisolone suppresses central TSH secretion and inhibits peripheral deiodinase enzymes, reducing conversion of T4 into active T3.
Monitor Free T4 and TSH levels during prolonged or high-dose systemic corticosteroid therapy; clinical re-evaluation is advised.
Last updated: Sep 25, 2026
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