This page explains what happens if Levothyroxine and Sertraline are taken together, according to official sources.
Reduced levothyroxine efficacy and elevated TSH with sertraline
Sertraline can reduce systemic thyroid hormone efficacy and trigger an increase in serum TSH, requiring levothyroxine dose titration.
Evaluate TSH concentrations approximately 6 to 8 weeks after commencing or titrating sertraline. Adjust levothyroxine dosage if TSH rises.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.