This page explains what happens if Lisinopril and Losartan are taken together, according to official sources.
Dual RAAS blockade: hyperkalemia, syncope, and renal damage
Dual blockade of the renin-angiotensin system provides no clinical benefit while exponentially increasing risks of hyperkalemia, severe hypotension, and acute kidney failure.
Dual therapy is strongly advised against by international clinical guidelines. Choose a single RAAS inhibitor and monitor potassium.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.