This page explains what happens if Losartan and Prednisolone are taken together, according to official sources.
Attenuated antihypertensive effect via steroid fluid retention
Prednisolone induces mineralocorticoid-mediated sodium retention, diminishing the blood pressure lowering action of losartan.
Track blood pressure during systemic steroid treatment. Adjust losartan dosage if readings rise above target.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.