This page explains what happens if Metronidazole and Simvastatin are taken together, according to official sources.
Metronidazole-induced elevation in simvastatin levels
Metronidazole can inhibit CYP3A4 simvastatin clearance, resulting in elevated statin concentrations and increased myopathy risk.
Monitor for muscle pain or tenderness during metronidazole therapy. Consider temporary statin pause during lengthy antibiotic courses.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.