This page explains what happens if Sertraline and Tramadol are taken together, according to official sources.
Life-threatening Serotonin Syndrome and lowered seizure threshold
Combining tramadol with sertraline significantly elevates synaptic serotonin, precipitating potentially fatal Serotonin Syndrome and lowering the convulsive threshold.
Avoid concurrent use whenever possible. If unavoidable, monitor vigilantly for autonomic instability, neuromuscular hyperreactivity, and mental status changes.
Talk to your doctor or pharmacist about these two medicines; don't stop a prescribed medicine on your own.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.