ModerateSimvastatin + Warfarin

Can you take Simvastatin and Warfarin together?

This page explains what happens if Simvastatin and Warfarin are taken together, according to official sources.

What happens

Modest potentiation of warfarin anticoagulation

Simvastatin can modestly enhance the effect of warfarin and increase INR. Check INR when starting or adjusting the simvastatin dose.

Recommended management

Assess INR when starting or altering simvastatin dosages, and observe for signs of bleeding.

Clinical references

Eur J Clin Pharmacol: Effect of Simvastatin on Warfarin Anticoagulation Nationwide Study (PMID 31201436)FDA drug label (DailyMed): simvastatinFDA drug label (DailyMed): warfarin

Last updated: Sep 25, 2026

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