This page explains what happens if Tramadol and Warfarin are taken together, according to official sources.
Potentiated anticoagulation and elevated INR
Tramadol can significantly increase INR and elevate bleeding incidence in patients receiving stable warfarin maintenance.
Check INR within 3 to 5 days of starting tramadol. Adjust warfarin dosage as indicated.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.