This page explains what happens if Metformin and Prednisolone are taken together, according to official sources.
Steroid-induced hyperglycemia and insulin resistance
Prednisolone antagonizes the hypoglycemic action of metformin by inducing marked hepatic gluconeogenesis and peripheral insulin resistance.
Perform frequent blood glucose monitoring during steroid therapy. Anticipate the need for antidiabetic dose escalation or temporary insulin addition.
Last updated: Sep 25, 2026
Before changing or stopping any medicine, ask your doctor or pharmacist. Never stop your medicine on your own.